No news internally !

Don't exaggerate - it was only -36% ;-)

Anyone knwo what this Subpoena is about?

http://www.reuters.com/article/2013/04/25/astrazeneca-results-factory-id...

-38%?
Oh dear, Cambridge seems so very far away

"Any thoughts or inside info on the restructuring/simplification in Pharm Dev that will be announced in early May?"

Sell your house, sell your kids, sell your qualifications and go live as a hermit.

Any thoughts or inside info on the restructuring/simplification in Pharm Dev that will be announced in early May?

Its 30 days minimum so employee reps may not have finished their deliberations yet.

AZ revised business plan found here:
crispian-jago.blogspot.se/2010/10/handy-alternative-therapy-flowchart.html

Some iMed functons are putting together a revised business plan in light of the anouncements made 1 month ago. These will now have been agreed in the leadership teams, and will be subject to confidential consultation for 30 days with or employee reps. Any employee reps want to spill the beans?

Should cover the cost of a decent pad in Cambridge

It seems better and at least optimistic to have a golden hello, far better than DBs golden handshake for doing a disastrous job.

the whole market is up (due to central bank intervention) but AZ is under-performing compared to other healthcare and pharma stocks.

They may lambast the golden hello but the share price is still performing very well. Someone believes he will deliver!!

U.K. funds lambaste AstraZeneca CEO's £4M 'golden hello'.

New poster to appear at all AZ sites:
http://www.iamrogue.com/images/stories2/posters/safehouse.jpg

"What will happen to HTS in AZ? Will it move to the fantasy new Cambridge site or will it be toast?"

the last 7yrs should tell you that any person, function or site in AZ is potentially toast, noone at AZ should get too comfortable.

In the absence of real news people crave any news. I can therefore let you know that HTS is to be established on a site in Leicestershire. Discussions are ongoing to buy the site from a plastics company who are currently maximizing this sites usage by storing bundles of recycling plastic in it's carpark.

What will happen to HTS in AZ? Will it move to the fantasy new Cambridge site or will it be toast?

What's the favoured site in Cambridge? Granta Park? Babraham?

oncology is not one of Soriot's five priorities

If Christies is so bad what is the world class oncology unit in Cambridge?

Site near Addenbrooks not preferred.

If you think the Christie is world class.. then you live in a fools paradise,. this link has screwed AZ oncology

The Charnwood site was sold for £1 - the rest must be worth a least a tenner of anybody's money...

Does anyone really know if or believe that there is anything worthwhile left to sell?

"He is restructuring to position for a sell off, rather obvious!"

how is it obvious ?

He is restructuring to position for a sell off, rather obvious!

I have been with AZ for sixteen years, but gave up 2 years ago and was lucky to get a job outside AZ. The big problem now for AZ R&D is that they restructure every 1-2 years. Even if every one of new reorganisations were genius (which I don’t think) they would have been destroyed by the next reorganisation before proven their possible success. In my experience the next reorganisation arrived just when you started to feel that; OK that last strategy was a very unconstructive shake up but now, a year later, we start to see how to work and it feel as we actually could find a way get efficient again. So about then BOOM the next genus’s strategy landed on top of everyone’s back.

"senior people in pharmaceutical companies should be paid for the new products that they deliver
But restructuring is what they do when they don't have any - it leads to less likelyhood of new products as everyone is demotivated and searching for new jobs/roles. However, it protects profits and EPS so the shareholders support it.

Restructuring is all the rage, but it's a lot easier than actually inventing and marketing new products. Perhaps senior people in pharmaceutical companies should be paid for the new products that they deliver rather than their fruitless reorganisations. One wonders why the shareholders don't say something.

1) They are most likely nepotistic institutional shareholders
2) They can simply sell their shares indirectly

Restructuring is all the rage, but it's a lot easier than actually inventing and marketing new products. Perhaps senior people in pharmaceutical companies should be paid for the new products that they deliver rather than their fruitless reorganisations. One wonders why the shareholders don't say something.

AstraZeneca's new strategy gets thumbs down from S&P 08.04: S&P doesn't buy AstraZeneca CEO's revamp plan.

http://www.magic8.co.uk/ask

What/Who is the magic 8 ball? Damn I wish i kept up with nicknames...

Well, the magic eight ball has his ticket booked for Cambridge

How the new R&D IS will be formed? From all old school boys of Rsearch Informatics VP and current RDI site leader does not talk to his own staff!

"It was a nice Silver Cross pen and pencil at Charwood. Anyone remember "Crackerjack" on TV?"

And 1.75 times annual salary. :)

It was a nice Silver Cross pen and pencil at Charwood. Anyone remember "Crackerjack" on TV?

It's now a painting of a Spitfire and a firm handshake.

Has the redundancy package changed? I heard a rumour it had

That's my feeling too. I just cant see Cambridge happening

Having left AZ a few years ago, I've lost track of the pipeline. How many compounds do AZ currently have in Phase II & III?

Never undersrood taking this one on, it had poor efficacy prevously but AZ insisted those were flawed studies (as usual).

Surely this is no 'news'... ok so its official now, but this mist have been on the cards for several weeks about this phase 3.

More bad news! The licensed Rigel cmpd for rheumatoid arthritis has failed one of the 2 primary end points in Phase 3. Also efficacy and side effect profile look inferior to Humira (a cmpd I worked on years ago when it belonged to BASF)

2nd Rate begats 2nd rate as AZ fly in smaller and smaller circles.

How long before the beak touches the bottom?

http://tinyurl.com/2ndrate

The fact that everyone in the industry knew AP was on borrowed time for the last 3 years and still such practices continued right to the bitter end speaks volumes about the culture there

"The selection process at AP used to (does it still?) involve pitting candidates against each other such that the ones that best mimicked an expected artifically competitive stereotypic behaviour got the job. And you wonder why everyone was/is the same"

Nail on head.

Ex AZ here; I also predict that no building will take place in Cambridge. My prediction is a complete withdrawal from UK R&D after AP has been run to a standstill over the next 4 to 6 years. Multiple changes of the SET followed by a resignation from PS some time in 2017 when the shit has really hit the fan. Plan your exit now you are on a very extended notice period!

"Modern labs WERE Charnwood. All still in excellent condition at closure. Nice campus feel, where projects were innovative. None of this 'oh look, another quinazoline into development' mentality. High risk/high gain approaches to R&I.
AP should have gone way before Cwd."

Sorry - Cwd was indeed better then than AP, but both had (and maybe still have?) the same sense of self-entitlement, ingrained over-bureaucratic processes, narrow thinking and more than a few crap leaders.

That being said - why is poor management always someone elses problem in this thread? If your site takes it in the shorts, it is not just "the managers fault" - it might just be your own too. Whatever level you were or are. Think about it.

I have a related theory. The selection process at AP used to (does it still?) involve pitting candidates against each other such that the ones that best mimicked an expected artifically competitive stereotypic behaviour got the job. And you wonder why everyone was/is the same?