They're very thin right now. Hoping for a partner/buyout, I think. They do monitor the boards though.

Shame, was a nice idea back in 2000

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Is it time for the annual Lex Layoff?

Princeton will be done-they are looking to get out of their place now.

The Woodlands will probably continue to trim the therapeutic areas that haven't come up with anything (Oncology and Biotherapeutics were the first two to go as I remember....)I would guess that the screening bunch and what's left of R&D will be done as well.

Probably just what few compounds they have and clinical left. Drugs in search of a disease (or $). The Sands dream of being the next Microsoft is history.

in a time frame of one year, what do you think will be left of Princeton and the Woodlands?

the stock price is up, champagne is flowing....no worries, no problems

nothing to do???? no no reports, conferences, collaborations are all ongoing. oh...and the lawn looks beautiful.

I understand that the Princeton site is closing down. They are at least trying to get out of the old Lucent building that they have been in for quite some time. Most of the chemists are gone and there's nothing to do. The Woodlands is likely next.

Maybe JS can have a glass with his rabbit-LOL

Actually he told me that story once of being totally offended over someone in a trailor park in Raleigh, NC keeping their Claret in the fridge. Also told me his dentist back in the old country used a foot pedal to drive his drill. Then of course he went on to describe people in Texas as not quite wearing shoes yet....

hopefully TX has imported some of Chateau Main in case of diaster

Almost inevitably after there's an update here, Lance I. goes trolling my LinkedIn. ReallY ??? Go back and play in your survivalist bunker. Naw, Lance is actually a pretty decent guy, just a little peculiar. He'll probably go live in his bomb shelter with all of his Post apocalypse trappings when Arthur's dream finally collapses.

People of the Woodlands, guard your household pets in case this happens !

"I remember about the rabbits, George."

"The hell with the rabbits. That’s all you can ever remember is them rabbits."

NJ had a slew of former BMS and other natural products chemists. Arthur had his cronies in The Woodlands. He'd take people right out of post doc and make them directors with inflated salaries. There were also examples of mouse target data coming out of thin air. (BM) I can't see The Woodlands or NJ lasting much longer.

they don't need research, just outsource. NJ is a joke led by a big pharma recycle

they did hype the business plan, keeping the best for themselves!

'of mice and men' you're right, paradise is lost, the forces of evil have taken over

I think that AS fancies himself as George, but he's more like Lennie breaking the neck of every soft thing he touches. The Woodlands campus was always beautiful in the summertime with turkey vultures circling overhead. It will be sad to see it go.

"...A water snake glided smoothly up the pool, twisting its periscope head from side to side; and it swam the length of the pool and came to the legs of a motionless heron that stood in the shallows. A silent head and beak lanced down and plucked it out by the head, and the beak swallowed the little snake while its tail waved frantically..."

"Of Mice and Men"
John Steinbeck

NJ is a waste land, so much space and so few people. The grandiose plans of men for mice.

I suspect that Perry's next oppnent (who will likely trounce him now that he's made a fool of himslef and left the state in a financial mess with respect to education, etc.)will hammer him for this.

They already didn't do the promised hiring for the Texas money and there weren't any consequences, so I doubt that things will get ugly when they shutter the place. The politicians got their cut and that's good enough to keep them quiet. The free market at its best.

wow! the combination of knockouts and combichem led to little. If they don't do the hiring promised for the TX money, do things get 'ugly' in the Woodlands?

Talk about a poke in the eye...there's a letter in Nature Biotechnology this month on Bruton's Tyyrosine Kinase by a former researcher there who said, "....gave us some degree of pause when reflecting on the use of “knockout” mice for drug discovery applications...." as the last sentence.

what??? you don't mean the 10 to 10 initiative do you? or the 10 great compounds? or the best pipeline? or........

Amazed it's lasted so long with diddly squat to show.

The rumor is that Invus will shutter the place at the end of the year now that they have control of the situation. For the lucky senior people who were there since the beginning or relatively close to retirement, they'll probably be okay. But it will be very ugly for the remaining employees. Sad to beleiev that they opened thier beutiful new facility in 2002 and then started laying off people and departments just 5 years later. Quite a few poor decisions made by Arthur, Brian, and their lap dogs.

Thats' probably just about it for biotech in The Woodlands. So many companies have died there.

after all of the denial, the recent 10Q finally revealed the annual layoffs. the hype

While I agree that AT being thrown under the bus shows some signs of starting to cut into the quick, I don't think that the end is within sight until AA gets shown the door.

More like 30 from Texas and 26 in NJ and Arthur's prized minion, AT, is in the body count. This must be the end if that sacred cow got put out to pasture. He was awful.

This is what's left of LXRX- inane drivel. Oh well, the word is that R&D will shut down this year. 22 people went today. The only thing keeping the chemists in NJ is the lack of any type of decent employment in NJ.

The Woodlands situation appears to be more or less along "party lines" with the suckups, Arthur's cronies, and a few competent people left.

A bit touchy aren't we. Poke a little fun at Good Sir Layoffalot the Knave and find your comments jettisoned into the abyss. Little did I know that I had wandered into the neighbourhood of the Gorge of Eternal Peril. I'll keep my "Guide to the Average Airspeed Velocities of Passerines" handy.

Well this could have been predicted after the failure of the LX-694U program.

Racist !!!! That's pretty funny. Story has it that one of the department heads (no longer there) used to routinely have discussions (in English no less) about how inferior Americans were.

The guy you mention is doing very well and is hardly racist as he manages an international biotech portfolio now.

Pharm D is supposedly going down to about 8 people. Heard from a former NJ guy who's now in academics that NJ looks pretty bleak too. If AT and AA remain, then that pretty much proves that Arthur is retaining his cronies who really have no skills.

Amusing to me that they clung to the same old, same old, drug screening mantra with the idea that their uni-dimensional KO approach was going to find all of these great targets that no one else had discovered. They trashed and shut down biotherapeutics when that's the direction the rest of the industry went. If they had quality people in BT, then they might be sustainable.

Arthur Sands wasted quite a bit of investor's money but this place is pretty reminiscent of Celera, Curagen, Exelixis, etc. The "Post Genomics Bust".

Not surprising. Now that Invus owns the show, I'm sure they will want some discipline on the burn rate. Has anyone heard more on the cuts? Are they still operating a site in NJ?

Is there anyone left to lay off? What does go on in The Woodlands these days? Can't imagine there's anyone doing R&D these days, so we must be down to the hard core of Sands cronies by now.